I am having a related issue: After using “live connect” with Unity for the first time, my audio channels of my interface (RME UFX+) are offset by a few channels and I am unable to switch to any other Core audio device from the list in FMOD.
Restarted FMOD and computer and am not running live connect or even Unity at all now.
I am also unaware of how I could switch the channels back to how they were, which is what is currently configured in audio midi settings (I checked settings in AMS for stereo, 5.1 Surround 2.0 and all others- all correct and how they were before).
Switching the default system audio (osx menu speaker icon) to another device has no effect for FMOD; but switches all other running audio applications. (None of them are running while I am experiencing the issue I described).