Invoking EventInstance.start and EventDescription.createInstance many times might increase the frequency of this crash, but I don’t think it will be the main reason for the crash.
This might help us a little, but first I think it would be best to enable logging and look at the log when this crash occurs. Can you please tick Enable API Error Logging , set your Logging Level to “Log”, and post the output of your game’s log here?
Attaching the FMOD Studio Profiler and recording a Profiler Session should allow you to record any pops, clicks, or performance problems you are experiencing. After that you can export your Profiler Session with Package Selection, and upload it to your FMOD Profile so we can have a look too.